Gene-edited 2013 Bat Cornavirus Ratg13

Discussion in 'OFF TOPIC SUBJECTS' started by CULCULCAN, May 18, 2020.

  1. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    Finally solved it, how someone made Covid-19!

    They gene-edited a 2013 bat coronavirus RaTG13 from Yunan,

    to place a furin-cleavage site in its "spike" protein.

    No other amino-acid changes nearby.

    Just a precise change in one place. CRISPR Cas9.

    EYS2L23VAAInkGI.
     
  2. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    EYTH9xFWsAE-Sga?format=&name=large.
     
  3. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    Evidence grows

    that Coronavirus

    was man-made:

    the bat virus it

    “evolved” from

    appears to be faked

    corona-virus-300x227.
    The claims that the current pandemic Coronavirus
    is natural all rely on it being 96% closely related
    to a natural bat virus known as the RaTG13 virus.


    But new analysis suggests this “natural” virus only
    exists as a fake creation on a Chinese computer.


    The implications of this type of work will affect global politics.

    The anger towards the Chinese CCP mismanagement,
    dishonesty, and the coverup will unite the world
    against the global bad-citizen player.

    It also drives a pike through the casual globalist academic programs,
    and the role of people like Anthony Fauci, chief advisor to Trump,
    head of the Expert Swamp in the US.

    Why was he sending money to the Wuhan Institute of Virology?

    Why did the West help train and supply this lab?

    h/t ramblingidiot, Choroin, Selwyn, El Gordo, Rob Dinn, Mike Mitchell

    The virus that SARS-CoV-2 is supposed to have evolved
    from looks unmistakably artificial
    — in sections it contains far too many “mutations”
    that matter but hardly any of the normal noise o
    f silent mutations which always occur naturally alongside
    the mutations which change the end product.

    Like someone cut and pasted multiple photos together
    with different background noise.

    Other sections of the code which ought to mutate quickly
    are suspiciously identical and unchanged,
    and didn’t mutate at all.

    (In the wild there is little selective pressure on something
    called “E Proteins” and they vary a lot in other coronaviruses.

    They are already mutating fast in the pandemic
    but somehow were “frozen” in time in RaTG13.)

    Dr. Shi Zhengli is known as the Bat Woman of Wuhan Virology.

    We’ve already heard how her lab was central to research
    on Coronaviruses and how she and others were
    ordered to destroy all copies
    of the laboratory viruses
    on Jan 2nd this year in what appears to be a mass cover up.

    A string of papers were released in February claiming
    the Wuhan Virus was “96% related” to a known Bat Coronavirus
    and was therefore natural
    (see Zhao et al 2020, Shan-Lu Liu, 2020,
    Andersen et al 2020).

    Two of these papers appeared in Nature.
    But what we didn’t know was that the RNA sequence
    for the original bat Coronavirus that the new pandemic evolved from,
    which was called RaTG13, was only registered on Jan 27th this year,
    despite it supposedly being discovered in 2013.

    The first Nature paper appeared only 6 days later.

    So much for Peer Review…
    No one has a sample of that virus, no one else has sequenced it,
    and it, as Steven Mosher says may only exist
    “in a string of letters on her computer”.

    NerdHasPower describes how easy it is to create
    a “natural bat virus” that matches the Wuhan virus:

    Can the sequence of such a virus be fabricated?

    It cannot be any easier.

    It takes a person less than a day to TYPE such a sequence
    (less than 30,000 letters) in a word file.

    And it would be a thousand times easier
    if you already have a template that is about 96% identical
    to the one you are trying to create.

    Once the typing is finished,
    one can upload the sequence onto the public database.

    Contrary to general conception,
    such database does not really have a way
    to validate the authenticity or correctness
    of the uploaded sequence.

    It relies completely upon the scientists themselves
    – upon their honesty and consciences.

    Once uploaded and released, such sequence data
    becomes public and can be used legitimately
    in scientific analysis and publications.

    NerdHasPower, with several helpers, shows there are sections
    which are missing the silent mutations which would normally
    occur in a virus due to natural mutation.

    Think of these as the noise that should be there,
    but isn’t.

    The lack of this background noise shows the mutations
    were “designed” by the hand of man (or woman, in this case)
    with an aim in mind.

    He points out that scientists like Zhengli w
    ould not sit on a hot new natural bat virus
    like RaTG13 for six or seven long years without publishing it.

    The first thing they would do is analyze it for sequences
    that show whether it would bind to human ACE2 receptors like SARS did
    — making it a potential human threat.

    It’s exactly the kind of discovery researchers are hunting for,
    the kind that make that researcher a highly cited, author.

    As an expert as Shi is, she only needed to take one peek
    at the sequence of RaTG13’s RBD and immediately realize:

    this virus closely resembles SARS in its RBD
    and has a clear potential of infecting humans.

    If Shi’s public statement is true and she indeed intends
    to discover bat coronaviruses with a potential to cross-over to humans,
    how could she possibly overlook this extremely interesting finding
    of RaTG13?

    If this RaTG13 was discovered SEVEN years ago in 2013,
    why did Shi not publish this astonishing finding earlier
    and yet let the “less-attractive” viruses take the stage?

    Why did she decide to publish such a sequence only
    when the current outbreak took place
    and people started questioning the origin of the Wuhan coronavirus?

    None of these makes sense.

    These facts only add to the suspicion
    – Zhengli Shi either was directly involved
    in the creation of this virus/bioweapon, or helped cover it up, or both.

    Steven Mosher has done a masterful job of explaining
    the whole story of the master code cracking done by NerdHasPower,
    who published in Chinese and English
    and who says only he is “A Nobody Scientist”.

    Presumably honest Chinese scientists need to be nobodies.
    Was the coronavirus created by Chinese scientist who tried to cover her tracks – and failed?

    Steven Mosher:
    To reinforce the “Wet Market” cover story, namely,
    that this new pathogen had come from nature
    and not from her lab, something had to be done.

    And it had to be done quickly, since by then the China Coronavirus
    had spread to the rest of the world.

    Anger against China for its lack of transparency
    about the origins and characteristics of the virus was growing.

    The similarity between the two coronaviruses
    —including their common ability to infect humans
    –would greatly reinforce [Dr Shi Zhengli's]
    story that the SARS-CoV-2 had jumped
    from a bat to a human,
    perhaps through some intermediate species at the Wuhan wet market.

    So, all Dr. Shi had to do was sit down
    before her computer keyboard, open a word file,
    and begin to fabricate the SARS-CoV-2 analogue
    that she would claim to have found in nature seven years before.

    All she had to do was type in the genetic sequence of her own creation,
    SARS-CoV-2, changing a few nucleotides now and again
    to mimic the “random mutations” that regularly occur in nature.

    She could easily have completed the “data entry”
    part of her task in a day, since all she was doing
    was entering in a string of letters alternating
    between the four nucleotides, A, U, G, and C.

    And coronaviruses contain less than 30,000 different nucleotides.

    Dr. Shi registered her new virus on January 27th, 2020,
    with the National Center for Biotechnology Information (NCBI)
    of the U.S. National Institutes of Health, the customary repository
    for such information.

    She called it RaTG-13, Ra for Rhinolophus affinis,
    the Latin name of the Intermediate Horseshoe Bat,
    and 13 for 2013, the year she supposedly “discovered” it.

    A lot of people have been taken in by Dr. Shi’s clever “discovery,”
    which is looking more and more like a forgery.

    No one else has independently verified its existence.

    No other lab has a sample of it, and no one else has ever sequenced it.

    And of course, they likely never will,
    because more and more evidence suggest
    that it exists only in a string of letters on her computer.
    The case of the missing silent mutations

    NerdHasPower has shown that the changes
    that supposedly occurred by natural mutation
    from the wild RaTG13 virus to the SARS-Cov-2 virus
    have a very unnatural pattern.

    The code for RNA is a string of four letters A, T, C and G.

    Each Coronavirus is a string of these letters 29,000 bases long.

    It is the same code as all life on Earth
    (or it wouldn’t be able to be used inside our cells).

    The string is read as three letter codons (Eg: ATG, or ATC).

    Each three letter codon is translated into one particular amino acid,
    but there is redundancy built in to the code.

    So often one letter of each codon can mutate
    but still code for the same amino acid.

    This protects the code, so that most mutations
    won’t change the end product.

    They are “silent” mutations which don’t change the end product
    – they are the spelling error that can’t be heard
    — like reading Cat and Kat.

    (Synonymous mutants don’t change the meaning)

    Steven Mosher:
    In nature, the ratio of synonymous to non-synonymous
    is approximately 5:1.

    Here’s where Dr. Shi got into trouble.

    When typing in the genomic sequence
    of her “discovery” she made way too many non-synonymous changes
    at the beginning.

    Then, one-third of the way through the sequence,
    she apparently realized her error.

    After that, she made way too few non-synonymous changes.

    So while the entire genome has the expected 5:1 ratio,
    there are stretches where the ratio is closer to 2:1,
    and other long stretches where it is as high as 44:1.

    Nature’s mutations are random.

    Dr. Shi’s “mutations” are not.

    Dr. Lawrence Sellin has calculated that the odds
    that her “mutations” occurred naturally in just one area

    —the critical spike protein

    –at almost ten million to one.
    Thank the Expert Swamp for help creating this virus

    Dr Anthony Fauci sent $US to do this work in China.

    Steven Mosher on Fauci’s role:

    …here is one thing about Dr. Shi’s research
    that we do know with absolute, ironclad certainty:

    The U.S. was helping to fund it.

    From 2013 onwards, the National Institute of Allergies
    and Infectious Diseases, run by the now-famous Dr. Anthony Fauci,
    gave $7.4 million for research involving gain-of-function work
    and collecting and studying bat coronaviruses,
    $600,000 of which went to the Wuhan Institute of Virology.

    Much of the rest went to other labs in China.

    If Dr. Fauci was as familiar with the Chinese Communist Party
    as he is with viruses, he would not have sent the Wuhan Institute
    of Virology one thin dime.

    He would have known that the PRC
    has a long-running program to develop bioweapons.

    He would have concluded that China’s only BSL-4 high containment lab
    was the obvious place to carry out at least some of this research.

    And he definitely did know that the “Gain-of-Function” research
    he was funding had the potential to create
    “Pathogens of Pandemic Potential”
    that might not be used for peaceful ends.
    NerdHasPower on the E proteins that don’t mutate

    The E protein of β coronaviruses is a structural protein
    that is tolerant of mutations as evidenced both in SARS
    and in bat coronaviruses.

    However, on the amino acid level, E protein
    of the Wuhan coronavirus identified at the beginning
    of the outbreak is 100% identical to those of the suspected templates,
    ZC45 and ZXC21 (Figure 4).

    What is striking is that, after a short two-months spread
    of the virus in humans, the E protein is already mutating.

    Sequence data obtained within the month of April
    indicate that mutations have occurred
    to four different locations (Figure 4).

    Note that the E protein makes very limited interactions
    with host proteins and thus is not under evolutionary pressure
    to adapt to a new host.

    Not only can the E protein tolerate mutations
    but also its mutational rate is held constant
    across different coronavirus species.

    The fact that the E protein of the Wuhan coronaviruses
    is already mutating in the short period of
    human-to-human transmission is consistent
    with its evolutionary feature.

    In stark contrast, while ZC45/ZXC21 and the Wuhan coronavirus
    are more distant evolutionarily, the E proteins within them
    are 100% identical.

    In no way this could be a result of natural evolution.

    Those who know genetics will get a lot out the collective investigation
    going on at NerdHasPower.
    Long live free speech.
    REFERENCES

    Zhao et al 2020 https://www.nature.com/articles/s41586-020-2012-7
    Shan-Lu Liu, 2020 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054935/
    Andersen et al 2020 https://www.nature.com/articles/s41591-020-0820-9

    http://joannenova.com.au/2020/05/is...MYu1r1rKtBSlr0SqYBedmdiRmTHKCse9f0efGT9V4LxUk
     
  4. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    Last edited: May 20, 2020
  5. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

    Messages:
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    EPtXN2BUYAAp620.
     
  6. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

    Messages:
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  7. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

    Messages:
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    Zika
    AIDS
    H1N1
    SARS
    Limes
    Ebola
    Coronavirus
    All lab created
    All patented
     
  8. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

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    DR. FAUCI was a key player
    in a "virus induced pandemic"
    10 years ago during the AIDS crisis
    and is still playing Dr. Mengele (Angel of Death) today
    with new buddy, Bill Gates.
    Dr. Robert Willner proves that the "virus" is a fraud
    by pricking his finger in numerous press conferences
    with HIV"

     
  9. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

    Messages:
    6,902
     
  10. CULCULCAN

    CULCULCAN The Final Synthesis - isbn 978-0-9939480-0-8 Staff Member

    Messages:
    6,902
    DOCTORS advertised Camel cigarettes .. DOCTORS stated that DDT, Thalidomide, Fluoride , STATINS, asbestos ... for a start .. did not harm us .. or were even beneficial .... 'SCIENTISTS state categorically that the earth is HEATING UP ...

    UAH-LT-global-thru-Apr-20201.

    ... ... SCIENTISTS state unequivocally that EMFs DO NOT DAMAGE us ... you know what you are talking about ..?????
     

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