Antibody-dependent Enhancement (ade)

antibody-dependent enhancement (ADE)

• here is the entire abstract:
  
  “Abstract
  
  Aims of the study: Patient comprehension is a critical part
  of meeting medical ethics standards of informed consent in study designs.
  
  The aim of the study was to determine if sufficient literature exists to require clinicians to disclose the specific risk that COVID-19 vaccines could worsen disease upon exposure to challenge or circulating virus.
  
  Methods used to conduct the study: Published literature
  was reviewed to identify preclinical and clinical evidence
  that COVID-19 vaccines could worsen disease
  upon exposure to challenge or circulating virus.
  
  Clinical trial protocols for COVID-19 vaccines were reviewed
  to determine if risks were properly disclosed.
  
  Results of the study: COVID-19 vaccines designed to elicit neutralising antibodies may sensitise vaccine recipients to more severe disease
  than if they were not vaccinated.
  
  Vaccines for SARS, MERS and RSV have never been approved,
  and the data generated in the development and testing
  of these vaccines suggest a serious mechanistic concern: \
  
  that vaccines designed empirically using the traditional approach
  (consisting of the unmodified or minimally modified coronavirus
  viral spike to elicit neutralising antibodies),
  
  be they composed of protein, viral vector, DNA or RNA
  and irrespective of delivery method, may worsen COVID-19
  disease via antibody-dependent enhancement (ADE).
  
  This risk is sufficiently obscured in clinical trial protocols
  and consent forms for ongoing COVID-19 vaccine trials
  that adequate patient comprehension of this risk is unlikely to occur,
  obviating truly informed consent by subjects in these trials.
  
  Conclusions drawn from the study and clinical implications:
  
  The specific and significant COVID-19 risk of ADE
  should have been and should be prominently
  and independently disclosed to research subjects
  currently in vaccine trials, as well as those being recruited
  for the trials and future patients after vaccine approval,
  in order to meet the medical ethics standard
  of patient comprehension for informed consent.
  
  https://pubmed.ncbi.nlm.nih.gov/33113270/

 

Aurora says:
“ COVID-19 vaccines designed to elicit neutralising antibodies
may sensitise vaccine recipients to more severe disease than if they were not vaccinated.

Vaccines for SARS, MERS and RSV have never been approved, and the data generated in the development
and testing of these vaccines suggest a serious mechanistic concern: that vaccines designed empirically
using the traditional approach (consisting of the unmodified or minimally modified coronavirus viral spike
to elicit neutralising antibodies), be they composed of protein, viral vector, DNA or RNA
and irrespective of delivery method, may worsen COVID-19 disease via antibody-dependent enhancement (ADE).

This risk is sufficiently obscured in clinical trial protocols and consent forms
for ongoing COVID-19 vaccine trials that adequate patient comprehension
of this risk is unlikely to occur, obviating truly informed consent by subjects in these trials.”
says Aurora !!!